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10.1016/0006-2944(70)90079-7 Biochem

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Most preclinical studies are conducted in young, healthy, genetically homogeneous male rodents, far removed from the heterogeneity of aging human populations with comorbidities such as hypertension, diabetes, or cerebrovascular disease

In addition, among systematically healthy subjects, urea, creatinine, and GFR were not significantly changed before or after NSPT, while cystatin C significantly decreased after 1-, 3-, and 6-month follow-up compared with the baseline value (Graziani et al., 2010)